OPTIMAL DOSING AND TIMING OF HIGH-DOSE CORTICOSTEROID THERAPY IN HOSPITALIZED PATIENTS WITH COVID-19: STUDY PROTOCOL FOR A RETROSPECTIVE OBSERVATIONAL MULTICENTER STUDY (SELECT)

BackgroundIn hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely.Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails.In critically ill patients, high-dose corticosteroids are often administered as salvag

Gerrett Brief1, Tobias Lammich2, Edgar Nagel3, Sabine Pfennigsdorf4, Christoph W Spraul5, Selwyn Ho61Facharzt für Augenheilkunde, Dortmund, Germany; 2Neubrandenburg, Germany; 3Augenarztpraxis Rudolstadt, Germany; 4Polch, Germany; 5Geiselhart, Ulm, Germany; 6Allergan Europe, Marlow, UKObjective: To assess the efficacy and tolerability of a

Abstract Background Proteolytic Clostridium botulinum is the causative agent of botulism, a severe neuroparalytic illness.Given the severity of botulism, surprisingly little is known of the population structure, biology, phylogeny or evolution of C.botulinum.The recent determination of the genome sequence of C.botulinum has essie cause and reflect

Abstract: Recently, the author suggested a simple and composite equation of state by incorporating fundamental thermodynamic properties like heat capacities into her earlier concise equation of state for gases collirio drop set based on free volume and molecular association / dissociation.This work brings new results for aqueous solutions, based on

Today, chemistry and nanotechnology cover molecular separations in liquid and gas states by aiding in the design of new nano-sized materials.In this regard, the synthesis and application of two-dimensional (2D) nanomaterials are current fields of research in which structurally defined 2D materials are being used in membrane separation either in sel